Reperfusion rather than ischemia drives the formation of ubiquitin aggregates after middle cerebral artery occlusion Academic Article uri icon

Overview

MeSH Major

  • Brain Ischemia
  • Infarction, Middle Cerebral Artery
  • Reperfusion Injury
  • Ubiquitin

abstract

  • The data demonstrate that reperfusion rather than ischemia leads to the appearance of ubiquitinated aggregates, which form in the absence of major tissue damage and are not correlated with decreased proteasomal peptidase activity. Ubiquitin aggregates may form in potentially viable brain tissue, which may be later recruited into infarction by factors independent of ubiquitination.

publication date

  • August 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3404229

Digital Object Identifier (DOI)

  • 10.1161/STROKEAHA.112.650416

PubMed ID

  • 22700531

Additional Document Info

start page

  • 2229

end page

  • 35

volume

  • 43

number

  • 8