Characterization of KRAS rearrangements in metastatic prostate cancer Academic Article uri icon

Overview

MeSH Major

  • Gene Rearrangement
  • Prostatic Neoplasms
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins

abstract

  • This is the first description of an oncogenic gene fusion of KRAS, one of the most studied proto-oncogenes. KRAS rearrangement may represent the driving mutation in a rare subset of metastatic prostate cancers, emphasizing the importance of RAS-RAF-MAPK signaling in this disease.

publication date

  • June 2011

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3227139

Digital Object Identifier (DOI)

  • 10.1158/2159-8274.CD-10-0022

PubMed ID

  • 22140652

Additional Document Info

start page

  • 35

end page

  • 43

volume

  • 1

number

  • 1