Alterations in brain activation during working memory processing associated with breast cancer and treatment: A prospective functional magnetic resonance imaging study Academic Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Frontal Lobe
  • Magnetic Resonance Imaging
  • Memory, Short-Term
  • Parietal Lobe

abstract

  • Significant frontal lobe hyperactivation to support WM was found in patients with breast cancer. Superimposed on this background, patients showed decreased frontal activation at M1, with partial return to the previously abnormal baseline at Y1. These functional changes correspond to frontal lobe regions where we previously reported structural changes in this cohort and provide prospective, longitudinal data that further elucidate mechanisms underlying cognitive effects related to breast cancer and its treatment.

publication date

  • July 10, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3397784

Digital Object Identifier (DOI)

  • 10.1200/JCO.2011.38.5674

PubMed ID

  • 22665542

Additional Document Info

start page

  • 2500

end page

  • 8

volume

  • 30

number

  • 20