Regenerative pulmonary medicine: potential and promise, pitfalls and challenges. Review uri icon

Overview

MeSH

  • Animals
  • Humans
  • Hypertension, Pulmonary
  • Lung Injury
  • Male
  • Models, Animal
  • Pulmonary Emphysema
  • Pulmonary Medicine
  • Stem Cell Transplantation

MeSH Major

  • Adult Stem Cells
  • Endothelial Cells
  • Lung Diseases
  • Mesenchymal Stromal Cells
  • Regenerative Medicine

abstract

  • Chronic lung diseases contribute significantly to the morbidity and mortality of the population. There are few effective treatments for many chronic lung diseases, and even fewer therapies that can arrest or reverse the progress of the disease. In this review, we present the current state of regenerative therapies for the treatment of chronic lung diseases. We focus on endothelial progenitor cells, mesenchymal stem cells, and endogenous lung stem/progenitor cells; summarize the work to date in models of lung diseases for each of these therapies; and consider their potential benefits and risks as viable therapies for patients with lung diseases. Cell-based regenerative therapies for lung diseases offer great promise, with preclinical studies suggesting that the next decade should provide the evidence necessary for their ultimate application to our therapeutic armamentarium. © 2012 The Authors. European Journal of Clinical Investigation © 2012 Stichting European Society for Clinical Investigation Journal Foundation.

publication date

  • August 2012

has subject area

  • Adult Stem Cells
  • Animals
  • Endothelial Cells
  • Humans
  • Hypertension, Pulmonary
  • Lung Diseases
  • Lung Injury
  • Male
  • Mesenchymal Stromal Cells
  • Models, Animal
  • Pulmonary Emphysema
  • Pulmonary Medicine
  • Regenerative Medicine
  • Stem Cell Transplantation

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3513384

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2362.2012.02667.x

PubMed ID

  • 22435680

Additional Document Info

start page

  • 900

end page

  • 913

volume

  • 42

number

  • 8