Marked, homogeneous, and early [ 18F]fluorodeoxyglucose-positron emission tomography responses to vemurafenib in BRAF-mutant advanced melanoma Academic Article uri icon

Overview

MeSH Major

  • Fluorodeoxyglucose F18
  • Indoles
  • Melanoma
  • Skin Neoplasms
  • Sulfonamides

abstract

  • FDG-PET is a useful marker of an early biologic response to vemurafenib. Little variability in PET response was found between lesions in individual patients, which suggested minimal intrapatient molecular heterogeneity. FDG-PET is a useful tool for the evaluation of the biologic impact of inhibiting mutant BRAF and may allow for the more effective development of novel agents.

publication date

  • May 10, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2011.39.1938

PubMed ID

  • 22454415

Additional Document Info

start page

  • 1628

end page

  • 34

volume

  • 30

number

  • 14