Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17- demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors Academic Article uri icon

Overview

MeSH Major

  • Benzoquinones
  • Lactams, Macrocyclic
  • Neoplasms

abstract

  • Population pharmacokinetic analysis of 17-DMAG found no significant covariate effects and considerable inter-individual variability; this implies a wide range of exposures in the population and which may affect treatment outcome. Patients treated with 17-DMAG may require therapeutic drug monitoring which could help achieve more uniform exposure leading to safer and more effective therapy.

publication date

  • July 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3383947

Digital Object Identifier (DOI)

  • 10.1007/s00280-012-1859-1

PubMed ID

  • 22450873

Additional Document Info

start page

  • 201

end page

  • 5

volume

  • 70

number

  • 1