Clinical importance of the drug interaction between statins and CYP3A4 inhibitors: A retrospective cohort study in The Health Improvement Network Academic Article uri icon

Overview

MeSH Major

  • Cytochrome P-450 CYP3A Inhibitors
  • Enzyme Inhibitors
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors

abstract

  • Overall, this study found no difference in the relative hazard of muscle toxicity, renal dysfunction, or hepatic dysfunction for patients prescribed a statin 3A4 substrate versus a statin non-3A4 substrate with CYP3A4 inhibitor concomitancy.

publication date

  • May 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3890414

Digital Object Identifier (DOI)

  • 10.1002/pds.3199

PubMed ID

  • 22422642

Additional Document Info

start page

  • 494

end page

  • 506

volume

  • 21

number

  • 5