Animal models for microbicide studies Academic Article Article uri icon

Overview

MeSH Major

  • Esophageal Achalasia
  • Esophagoscopy
  • Natural Orifice Endoscopic Surgery
  • Tomography, Optical Coherence

abstract

  • There have been encouraging recent successes in the development of safe and effective topical microbicides to prevent vaginal or rectal HIV-1 transmission, based on the use of anti-retroviral drugs. However, much work remains to be accomplished before a microbicide becomes a standard element of prevention science strategies. Animal models should continue to play an important role in pre-clinical testing, with emphasis on safety, pharmacokinetic and efficacy testing.

publication date

  • January 2012

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.2174/157016212799304715

PubMed ID

  • 22264049

Additional Document Info

start page

  • 79

end page

  • 87

volume

  • 10

number

  • 1