Prognostic relevance of integrated genetic profiling in acute myeloid leukemia Academic Article uri icon

Overview

MeSH Major

  • DNA Mutational Analysis
  • Induction Chemotherapy
  • Leukemia, Myeloid, Acute
  • Mutation
  • Risk Assessment

abstract

  • We found that DNMT3A and NPM1 mutations and MLL translocations predicted an improved outcome with high-dose induction chemotherapy in patients with AML. These findings suggest that mutational profiling could potentially be used for risk stratification and to inform prognostic and therapeutic decisions regarding patients with AML. (Funded by the National Cancer Institute and others.).

authors

publication date

  • March 22, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3545649

Digital Object Identifier (DOI)

  • 10.1056/NEJMoa1112304

PubMed ID

  • 22417203

Additional Document Info

start page

  • 1079

end page

  • 89

volume

  • 366

number

  • 12