Clustering high dimension, low sample size data using the maximal data piling distance Academic Article uri icon


MeSH Major

  • Acids
  • Bacterial Proteins
  • Enzyme Activation
  • Gene Expression Regulation, Bacterial
  • Mycobacterium tuberculosis
  • N-Acetylmuramoyl-L-alanine Amidase
  • Peptide Hydrolases
  • Stress, Physiological


  • We propose a new hierarchical clustering method for high dimension, low sample size (HDLSS) data. The method utilizes the fact that each individual data vector accounts for exactly one dimension in the subspace generated by HDLSS data. The linkage that is used for measuring the distance between clusters is the orthogonal distance between affine subspaces generated by each cluster. The ideal implementation would be to consider all possible binary splits of the data and choose the one that maximizes the distance in between. Since this is not computationally feasible in general, we use the singular value decomposition for its approximation. We provide theoretical justification of the method by studying high dimensional asymptotics. Also we obtain the probability distribution of the distance measure under the null hypothesis of no split, which we use to propose a criterion for determining the number of clusters. Simulation and data analysis with microarray data show competitive clustering performance of the proposed method.

publication date

  • April 2012



  • Academic Article


Digital Object Identifier (DOI)

  • 10.5705/ss.2010.148

Additional Document Info

start page

  • 443

end page

  • 464


  • 22


  • 2