Increased chitinase expression and fungal-specific antibodies in the bronchoalveolar lavage fluid of asthmatic children Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Fungal
  • Asthma
  • Chitinases
  • Mycoses

abstract

  • Compared with non-asthmatics, asthmatic children exhibited increased chitinase activity and increased YKL-40 levels in BALF. Increased IgG and IgA reactivity to fungal proteins in the BALF of asthmatics may reflect a local response to fungal infection. Our findings are consistent with and suggest a role for chitinases in asthma pathogenesis among Bronx children and provide serological evidence of an association between fungal infection and severe asthma.

publication date

  • April 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2222.2011.03886.x

PubMed ID

  • 22092749

Additional Document Info

start page

  • 523

end page

  • 30

volume

  • 42

number

  • 4