Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke Academic Article uri icon

Overview

MeSH Major

  • Hypoxia-Ischemia, Brain
  • Membrane Glycoproteins
  • Protein-Tyrosine Kinases
  • Recovery of Function
  • Tropomyosin

abstract

  • A small molecule agonist of tropomyosin-related kinase B improves functional recovery from stroke and increases neurogenesis when administered beginning 3 days after stroke. These findings provide proof-of-concept that targeting of tropomyosin-related kinase B alone is capable of promoting one or more mechanisms relevant to stroke recovery. LM22A-4 or its derivatives might therefore serve as "pro-recovery" therapeutic agents for stroke.

publication date

  • July 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3383889

Digital Object Identifier (DOI)

  • 10.1161/STROKEAHA.111.641878

PubMed ID

  • 22535263

Additional Document Info

start page

  • 1918

end page

  • 24

volume

  • 43

number

  • 7