Statins and pulmonary fibrosis the potential role of NLRP3 inflammasome activation Academic Article uri icon

Overview

MeSH Major

  • Carrier Proteins
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Idiopathic Pulmonary Fibrosis
  • Inflammasomes

abstract

  • Statin use is associated with ILA among smokers in the COPDGene study and enhances bleomycin-induced lung inflammation and fibrosis in the mouse through a mechanism involving enhanced NLRP3-inflammasome activation. Our findings suggest that statins may influence the susceptibility to, or progression of, ILD. Clinical trial registered with www.clinicaltrials.gov (NCT 00608764).

publication date

  • March 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3297101

Digital Object Identifier (DOI)

  • 10.1164/rccm.201108-1574OC

PubMed ID

  • 22246178

Additional Document Info

start page

  • 547

end page

  • 56

volume

  • 185

number

  • 5