Statins and pulmonary fibrosis the potential role of NLRP3 inflammasome activation
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Idiopathic Pulmonary Fibrosis
Statin use is associated with ILA among smokers in the COPDGene study and enhances bleomycin-induced lung inflammation and fibrosis in the mouse through a mechanism involving enhanced NLRP3-inflammasome activation. Our findings suggest that statins may influence the susceptibility to, or progression of, ILD. Clinical trial registered with www.clinicaltrials.gov (NCT 00608764).