Radiation impairs perineural invasion by modulating the nerve microenvironment Academic Article uri icon

Overview

MeSH Major

  • Cellular Microenvironment
  • Ganglia, Spinal
  • Nerve Tissue
  • Radiation

abstract

  • Radiation may impair PNI through not only direct effects on cancer cell viability, but also an independent interruption of paracrine mechanisms underlying PNI. RT modulation of the nerve microenvironment may decrease PNI, and hold significant therapeutic implications for RT dosing and field design for patients with cancers exhibiting PNI.

publication date

  • June 29, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3386941

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0039925

PubMed ID

  • 22768171

Additional Document Info

start page

  • e39925

volume

  • 7

number

  • 6