P16INK4a and ProEx C immunostains facilitate differential diagnosis of hyperchromatic crowded groups in liquid-based papanicolaou tests with menstrual contamination Academic Article uri icon

Overview

MeSH Major

  • Cell Cycle Proteins
  • Cervical Intraepithelial Neoplasia
  • Cyclin-Dependent Kinase Inhibitor p16
  • Menstruation
  • Nuclear Proteins
  • Uterine Cervical Dysplasia
  • Uterine Cervical Neoplasms

abstract

  • p16(INK4a) and ProEx C are sensitive markers for identifying significant lesions in Pap test specimens with menstrual contamination. Patchy/mosaic staining may be seen in benign endometrial tissue with tubal metaplasia, but strong, diffuse staining likely indicates HSIL or carcinoma. These findings can be helpful in interpreting hyperchromatic crowded groups in menstrual Pap specimens. Further study may be prudent, being aware of the small study group.

publication date

  • January 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1159/000332978

PubMed ID

  • 22236746

Additional Document Info

start page

  • 55

end page

  • 61

volume

  • 56

number

  • 1