iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS Academic Article uri icon


MeSH Major

  • ADAM Proteins
  • Carrier Proteins
  • Immunity, Innate
  • Lipopolysaccharides
  • Listeriosis
  • Shock, Septic
  • Tumor Necrosis Factor-alpha


  • Innate immune responses are vital for pathogen defense but can result in septic shock when excessive. A key mediator of septic shock is tumor necrosis factor-α (TNFα), which is shed from the plasma membrane after cleavage by the TNFα convertase (TACE). We report that the rhomboid family member iRhom2 interacted with TACE and regulated TNFα shedding. iRhom2 was critical for TACE maturation and trafficking to the cell surface in hematopoietic cells. Gene-targeted iRhom2-deficient mice showed reduced serum TNFα in response to lipopolysaccharide (LPS) and could survive a lethal LPS dose. Furthermore, iRhom2-deficient mice failed to control the replication of Listeria monocytogenes. Our study has identified iRhom2 as a regulator of innate immunity that may be an important target for modulating sepsis and pathogen defense.

publication date

  • January 13, 2012



  • Academic Article



  • eng

PubMed Central ID

  • PMC4250273

Digital Object Identifier (DOI)

  • 10.1126/science.1214448

PubMed ID

  • 22246778

Additional Document Info

start page

  • 229

end page

  • 32


  • 335


  • 6065