Somatic mitochondrial DNA mutations in early Parkinson and incidental lewy body disease Academic Article uri icon

Overview

MeSH Major

  • DNA, Mitochondrial
  • Lewy Body Disease
  • Mutation
  • Parkinson Disease

abstract

  • Somatic mutations in mitochondrial DNA (mtDNA) are hypothesized to play a role in Parkinson disease (PD), but large increases in mtDNA mutations have not previously been found in PD, potentially because neurons with high mutation levels degenerate and thus are absent in late stage tissue. To address this issue, we studied early stage PD cases and cases of incidental Lewy body disease (ILBD), which is thought to represent presymptomatic PD. We show for the first time that mtDNA mutation levels in substantia nigra neurons are significantly elevated in this group of early PD and ILBD cases.

publication date

  • June 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3383820

Digital Object Identifier (DOI)

  • 10.1002/ana.23568

PubMed ID

  • 22718549

Additional Document Info

start page

  • 850

end page

  • 4

volume

  • 71

number

  • 6