β-Adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells Academic Article uri icon

Overview

MeSH Major

  • Matrix Metalloproteinase 13
  • Myocytes, Cardiac
  • Receptor, PAR-1
  • Receptors, Adrenergic, beta
  • Transcriptional Activation

abstract

  • In this study, we demonstrate that β-AR stimulation leads to MMP-13 transactivation of PAR1 in both cardiac fibroblasts and cardiomyocytes and that this likely contributes to pathological activation of Gαq and ErbB receptor-dependent pathways in the heart. We propose that this mechanism may underlie the development of β-AR overstimulation-dependent cardiac dysfunction.

publication date

  • June 19, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3386307

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.111.066787

PubMed ID

  • 22610965

Additional Document Info

start page

  • 2993

end page

  • 3003

volume

  • 125

number

  • 24