Lipoprotein-associated phospholipase A 2 mass and activity and risk of cardiovascular disease in a population with high prevalences of obesity and diabetes: The strong heart study Academic Article uri icon

Overview

MeSH Major

  • 1-Alkyl-2-acetylglycerophosphocholine Esterase
  • Cardiovascular Diseases
  • Diabetes Complications
  • Obesity

abstract

  • In this population-based cohort enriched with dysmetabolic phenotypes, LpPLA(2) mass and activity showed divergent associations with CVD. The inverse relationship for LpPLA(2) mass is contrary to observations from predominantly nondiabetic populations and will require independent replication. Whether this finding relates to redistribution of LpPLA(2) to lipoprotein classes where it is less atherogenic or reflects incomplete measurement of LpPLA(2) mass associated with altered lipoprotein composition in insulin resistance warrants further investigation.

publication date

  • April 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3308309

Digital Object Identifier (DOI)

  • 10.2337/dc11-1639

PubMed ID

  • 22338104

Additional Document Info

start page

  • 840

end page

  • 7

volume

  • 35

number

  • 4