Differentially expressed genes in window trials are influenced by the wound-healing process: Lessons learned from a pilot study with anastrozole
Gene Expression Regulation, Neoplastic
10-d exposure to anastrozole resulted in dysregulation of 18/502 cancer-related genes, and Ki-67 was reduced in 54% of cases. FFPE samples demonstrated good correlation with frozen samples. However, changes in gene expression and increased Ki-67 in the control group suggest local effects of wound healing may represent a confounding factor in the interpretation of perioperative window trials.