Differentially expressed genes in window trials are influenced by the wound-healing process: Lessons learned from a pilot study with anastrozole Academic Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Gene Expression Regulation, Neoplastic
  • Nitriles
  • Triazoles
  • Wound Healing

abstract

  • 10-d exposure to anastrozole resulted in dysregulation of 18/502 cancer-related genes, and Ki-67 was reduced in 54% of cases. FFPE samples demonstrated good correlation with frozen samples. However, changes in gene expression and increased Ki-67 in the control group suggest local effects of wound healing may represent a confounding factor in the interpretation of perioperative window trials.

publication date

  • July 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4509686

Digital Object Identifier (DOI)

  • 10.1016/j.jss.2011.05.058

PubMed ID

  • 21777924

Additional Document Info

start page

  • 121

end page

  • 32

volume

  • 176

number

  • 1