Caspase-3 and prostaglandins signal for tumor regrowth in cancer therapy Review uri icon

Overview

MeSH Major

  • Apoptosis
  • Caspase 3
  • Cell Proliferation
  • Neoplasms
  • Prostaglandins

abstract

  • Chemo- and radio-therapeutic regimens frequently kill cancer cells by inducing apoptosis, a cell-death subroutine that involves the activation of a particular class of proteases called caspases. In a recent issue of Nature Medicine, Huang et al. (2011) show that caspase activation in dying tumor cells causes the release of soluble lipid messengers, notably prostaglandin E(2), that stimulate tumor cell proliferation. In this short review, we will discuss the clinical and therapeutic implications of these findings.

publication date

  • June 7, 2012

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/onc.2011.459

PubMed ID

  • 21963852

Additional Document Info

start page

  • 2805

end page

  • 8

volume

  • 31

number

  • 23