Interactions between commensal fungi and the C-type lectin receptor dectin-1 influence colitis Academic Article uri icon

Overview

MeSH Major

  • Colitis, Ulcerative
  • Colon
  • Fungi
  • Intestinal Mucosa
  • Lectins, C-Type

abstract

  • The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich fungal community that interacts with the immune system through the innate immune receptor Dectin-1. Mice lacking Dectin-1 exhibited increased susceptibility to chemically induced colitis, which was the result of altered responses to indigenous fungi. In humans, we identified a polymorphism in the gene for Dectin-1 (CLEC7A) that is strongly linked to a severe form of ulcerative colitis. Together, our findings reveal a eukaryotic fungal community in the gut (the "mycobiome") that coexists with bacteria and substantially expands the repertoire of organisms interacting with the intestinal immune system to influence health and disease.

publication date

  • June 8, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3432565

Digital Object Identifier (DOI)

  • 10.1126/science.1221789

PubMed ID

  • 22674328

Additional Document Info

start page

  • 1314

end page

  • 7

volume

  • 336

number

  • 6086