3′-deoxy-3′-[ 18F]fluorothymidine positron emission tomography for response assessment in soft tissue sarcoma: A pilot study to correlate imaging findings with tissue thymidine kinase 1 and Ki-67 activity and histopathologic response Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Combined Chemotherapy Protocols
  • Fluorodeoxyglucose F18
  • Ki-67 Antigen
  • Multimodal Imaging
  • Positron-Emission Tomography
  • Sarcoma
  • Thymidine Kinase
  • Tomography, X-Ray Computed

abstract

  • Marked reductions in [(18)F]FLT tumor uptake in response to neoadjuvant treatment were observed in most patients with sarcoma. However, these reductions were not specific for histopathologic response to neoadjuvant therapy. Furthermore, posttreatment [(18)F]FLT tumor uptake was unrelated to tumor proliferation by Ki-67 and TK1 staining. These results question the value of [(18)F]FLT PET imaging for treatment response assessments in patients with soft tissue sarcoma.

publication date

  • June 15, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3436595

Digital Object Identifier (DOI)

  • 10.1002/cncr.26630

PubMed ID

  • 22020872

Additional Document Info

start page

  • 3135

end page

  • 44

volume

  • 118

number

  • 12