Calbindin controls release probability in ventral tegmental area dopamine neurons Academic Article uri icon

Overview

MeSH Major

  • Dopamine
  • Dopaminergic Neurons
  • S100 Calcium Binding Protein G
  • Ventral Tegmental Area

abstract

  • Relatively little is known about the molecular control of midbrain dopamine release. Using high-fidelity imaging of pHluorin-tagged vesicular monoamine transporter 2 in dopamine neurons, we found that exocytosis was more loosely coupled to calcium entry than in fast synapses. In ventral tegmental area neurons, this allows exocytosis to be efficiently controlled by a native fast calcium buffer, calbindin-D28k, maintaining a lower vesicular release probability compared with substantia nigra neurons.

publication date

  • June 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3703651

Digital Object Identifier (DOI)

  • 10.1038/nn.3099

PubMed ID

  • 22544312

Additional Document Info

start page

  • 813

end page

  • 5

volume

  • 15

number

  • 6