Galectin-1, a gene preferentially expressed at the tumor margin, promotes glioblastoma cell invasion Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Galectin 1
  • Gene Expression Regulation, Neoplastic
  • Glioblastoma

abstract

  • In conclusion, cells at the margin of glioblastoma, in comparison to tumor core cells, have enhanced expression of mediators of invasion. Galectin-1 is likely one such mediator. Previous studies, along with the current one, have proven galectin-1 to be important in the migration and invasion of glioblastoma cells, in GBM neoangiogenesis, and also, potentially, in GBM immune privilege. Targeting this molecule may offer clinical improvement to the current standard of glioblastoma therapy, i.e. radiation, temozolomide, anti-angiogenic therapy, and vaccinotherapy.

publication date

  • May 14, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3407025

Digital Object Identifier (DOI)

  • 10.1186/1476-4598-11-32

PubMed ID

  • 22583806

Additional Document Info

start page

  • 32

volume

  • 11