Targeting the interleukin-6/jak/stat pathway in human malignancies Review uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Interleukin-6
  • Janus Kinases
  • Neoplasms
  • STAT Transcription Factors
  • Signal Transduction

abstract

  • The Janus kinase/signal transducer and activator of transcription (Jak/Stat) pathway was discovered 20 years ago as a mediator of cytokine signaling. Since this time, more than 2,500 articles have been published demonstrating the importance of this pathway in virtually all malignancies. Although there are dozens of cytokines and cytokine receptors, four Jaks, and seven Stats, it seems that interleukin-6-mediated activation of Stat3 is a principal pathway implicated in promoting tumorigenesis. This transcription factor regulates the expression of numerous critical mediators of tumor formation and metastatic progression. This review will examine the relative importance and function of this pathway in nonmalignant conditions as well as malignancies (including tumor intrinsic and extrinsic), the influence of other Stats, the development of inhibitors to this pathway, and the potential role of inhibitors in controlling or eradicating cancers.

publication date

  • March 20, 2012

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3341105

Digital Object Identifier (DOI)

  • 10.1200/JCO.2010.31.8907

PubMed ID

  • 22355058

Additional Document Info

start page

  • 1005

end page

  • 14

volume

  • 30

number

  • 9