Composite chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma are biclonal lymphomas: A report of two cases Academic Article uri icon


MeSH Major

  • B-Lymphocytes
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Lymphoma, Follicular


  • Composite lymphomas (CLs) consisting of 2 indolent B-cell lymphomas are rare. We present 2 CL cases composed of chronic lymphocytic leukemia (CLL) and follicular lymphoma (FL), each with unique clinicopathologic features. In the first case, the FL was negative for IGH-BCL2 and harbored a novel IGH-associated translocation; in the second case, the CL manifested in the skin. The individual components in both CLs were derived from different B-cell clones. This is the first complete characterization, including molecular analysis, of CLs composed of leukemic CLL and FL and the first report of a cutaneous CL derived from 2 low-grade B cell lymphomas. Our results provide additional supporting evidence that CLs of indolent B-cell lymphomas are biclonal and suggest that they are pathogenetically different from CLs composed of a low-grade B-cell lymphoma and an aggressive B-cell lymphoma or Hodgkin lymphoma, which are usually clonally related.

publication date

  • April 2012



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1309/AJCPHXO5UGW2OELA

PubMed ID

  • 22431543

Additional Document Info

start page

  • 647

end page

  • 59


  • 137


  • 4