A gene signature based method for identifying subtypes and subtype-specific drivers in cancer with an application to medulloblastoma
Copy number aberrations (CNAs) are frequently found in cancer genomes and believed to be tumorigenic. Unfortunately, CNAs often occur in wide regions of the cancer genome that harbor a large number of genes, making it a challenge to identify the candidate cancer drivers. Further, subtypes of cancer may be characterized with distinct CNA patterns and hence have different drivers. © 2012 IEEE.
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