Muscling in on pgc-1α for improved quality of life in ALS Article uri icon

Overview

MeSH Major

  • Carcinoma
  • Heart Neoplasms
  • Melanoma
  • Neoplasms
  • Sarcoma

abstract

  • Impaired activity of peroxisome proliferator-activated receptor (PPAR)-γ coactivator (PGC)-1α has been implicated in the pathophysiology of several neurodegenerative disorders. In this issue, Da Cruz et al. (2012) show improved muscle function, but not survival, with increased PGC-1α activity in muscle in a mouse model of amyotrophic lateral sclerosis.

publication date

  • May 2, 2012

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2012.04.015

Additional Document Info

start page

  • 567

end page

  • 9

volume

  • 15

number

  • 5