Randomized phase II trial of sunitinib on an intermittent versus continuous dosing schedule as first-line therapy for advanced renal cell carcinoma Academic Article uri icon


MeSH Major

  • Carcinoma, Renal Cell
  • Indoles
  • Kidney Neoplasms
  • Pyrroles


  • Median time to tumor progression was 9.9 months for schedule 4/2 and 7.1 months for the CDD schedule (hazard ratio, 0.77; 95% CI, 0.57 to 1.04; P = .090). No significant difference was observed in overall survival (23.1 v 23.5 months; P = .615), commonly reported adverse events, or patient-reported kidney cancer symptoms. Schedule 4/2 was statistically superior to CDD in time to deterioration, a composite end point of death, progression, and disease-related symptoms (P = .034). CONCLUSION; There was no benefit in efficacy or safety for continuous dosing of sunitinib compared with the approved 50 mg/d dose on schedule 4/2. Given the numerically longer time to tumor progression with the approved 50 mg/d dose on schedule 4/2, adherence to this dose and schedule remains the treatment goal for patients with advanced RCC.

publication date

  • April 20, 2012



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2011.36.4133

PubMed ID

  • 22430274

Additional Document Info

start page

  • 1371

end page

  • 7


  • 30


  • 12