The expanding role of miR-302-367 in pluripotency and reprogramming Academic Article uri icon

Overview

MeSH Major

  • Cellular Reprogramming
  • Embryonic Stem Cells
  • MicroRNAs

abstract

  • MicroRNA (miRNA) has been shown to be essential for regulating cell fate and pluripotency; however, our knowledge of miRNA function in stem cells is incomplete due to experimental limitations and difficulties in identifying their physiological targets. Recent studies implicated hESC-expressed miRNAs (miR‑302-367 and miR‑371-373 clusters) in regulating BMP signaling and promoting pluripotency, suggesting that low levels of BMP signaling may promote pluripotency by preventing neural induction. A comprehensive list of miR‑302-367 targets recently identified by genome-wide approaches suggests a number of additional cellular processes and signaling pathways whose regulation by miR‑302-367 may promote pluripotency and reprogramming, such as cell cycle, epigenetic changes, metabolism and vesicular transfer.

publication date

  • April 15, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.4161/cc.19846

PubMed ID

  • 22436490

Additional Document Info

start page

  • 1517

end page

  • 23

volume

  • 11

number

  • 8