Role of immunohistochemistry in diagnosing renal neoplasms when is it really useful? Review uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Carcinoma
  • Immunohistochemistry
  • Kidney Neoplasms

abstract

  • Some of the most important and useful markers for the diagnosis of renal neoplasm include cytokeratins, vimentin, PAX2, PAX8, RCC marker, CD10, E-cadherin, kidney-specific cadherin, parvalbumin, claudin-7, claudin-8, α-methylacyl coenzyme A racemase, CD117, TFE3, thrombomodulin, uroplakin III, p63, CD57, and carbonic anhydrase IX. Each marker has its diagnostic role in a specific diagnostic setting. The common diagnostic situations that call for immunohistochemical staining are differential diagnoses of renal versus nonrenal neoplasms, histologic subtyping of renal cell carcinoma, diagnosis of rare primary renal neoplasms, diagnosis of renal neoplasms in small core-biopsy specimens, diagnosis of possible metastatic renal carcinomas, and less frequently, molecular prognostication.

publication date

  • April 2012

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.5858/arpa.2011-0472-RA

PubMed ID

  • 22458903

Additional Document Info

start page

  • 410

end page

  • 7

volume

  • 136

number

  • 4