Repertoire enhancement with adoptively transferred female lymphocytes controls the growth of pre-implanted murine prostate cancer Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Immunotherapy, Adoptive
  • Prostatic Neoplasms

abstract

  • This study shows that adoptively transferred female lymphocytes, particularly CD4 T cells, can control the outgrowth of pre-implanted prostatic adenocarcinoma cells. This approach does not significantly worsen graft-versus-host responses suggesting it may be viable in the clinic. Further, enhancing the available immune repertoire with female-derived T cells may provide an excellent pool of prostate cancer reactive T cells for further augmentation by combination with either vaccination or immune regulatory blockade strategies.

publication date

  • April 6, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3320876

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0035222

PubMed ID

  • 22493742

Additional Document Info

start page

  • e35222

volume

  • 7

number

  • 4