Host immune transcriptional profiles reflect the variability in clinical disease manifestations in patients with staphylococcus aureus infections Academic Article uri icon

Overview

MeSH Major

  • Adaptive Immunity
  • Blood Proteins
  • Community-Acquired Infections
  • Gene Expression Profiling
  • Host-Pathogen Interactions
  • Immunity, Innate
  • Staphylococcal Infections
  • Staphylococcus aureus

abstract

  • Staphylococcus aureus infections are associated with diverse clinical manifestations leading to significant morbidity and mortality. To define the role of the host response in the clinical manifestations of the disease, we characterized whole blood transcriptional profiles of children hospitalized with community-acquired S. aureus infection and phenotyped the bacterial strains isolated. The overall transcriptional response to S. aureus infection was characterized by over-expression of innate immunity and hematopoiesis related genes and under-expression of genes related to adaptive immunity. We assessed individual profiles using modular fingerprints combined with the molecular distance to health (MDTH), a numerical score of transcriptional perturbation as compared to healthy controls. We observed significant heterogeneity in the host signatures and MDTH, as they were influenced by the type of clinical presentation, the extent of bacterial dissemination, and time of blood sampling in the course of the infection, but not by the bacterial isolate. System analysis approaches provide a new understanding of disease pathogenesis and the relation/interaction between host response and clinical disease manifestations.

publication date

  • April 4, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3319567

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0034390

PubMed ID

  • 22496797

Additional Document Info

start page

  • e34390

volume

  • 7

number

  • 4