Regulation of adipogenesis by lymphatic fluid stasis: Part II. Expression of adipose differentiation genes Academic Article uri icon

Overview

MeSH Major

  • Adipogenesis
  • Adiponectin
  • CCAAT-Enhancer-Binding Protein-beta
  • Lymph
  • Lymphedema
  • Subcutaneous Fat

abstract

  • The mouse-tail model of lymphedema demonstrates pathologic findings similar to clinical lymphedema, including fat deposition and fibrosis. The authors show that lymphatic fluid stasis potently up-regulates the expression of fat differentiation markers both spatially and temporally. These studies elucidate mechanisms regulating abnormal fat deposition in lymphedema pathogenesis and therefore provide a basis for developing targeted treatments.

publication date

  • April 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3445411

Digital Object Identifier (DOI)

  • 10.1097/PRS.0b013e3182450b47

PubMed ID

  • 22456356

Additional Document Info

start page

  • 838

end page

  • 47

volume

  • 129

number

  • 4