T-cell/histiocyte-rich large B-cell lymphoma: A clinicopathologic distinct subtype of diffuse large B-cell lymphoma
Lymphoma, Large B-Cell, Diffuse
T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a morphologic subtype of diffuse large B-cell lymphoma and is characterized by the predominance of nonneoplastic T cells and histiocytes admixed with a small number of large neoplastic B cells. It is a biologically distinct disease characterized by male preponderance, advanced-stage disease at initial presentation, and high incidence of extranodal dissemination. T-cell/histiocyte-rich large B-cell lymphoma can potentially be misdiagnosed owing to its morphologic and/or immunophenotypic resemblance to other lymphomas, particularly nodular lymphocyte predominant Hodgkin lymphoma. Immunohistochemical evaluation for both the neoplastic and reactive components is essential for a correct diagnosis of this entity. We present 2 THRLBCL cases from our pathology archives and discuss the morphologic, immunophenotypic, molecular and biologic features of THRLBCL, with particular attention to its differential diagnoses. © 2012 Lippincott Williams & Wilkins, Inc.
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