Systematic review: Cardiovascular safety profile of 5-HT 4 agonists developed for gastrointestinal disorders
Serotonin 5-HT4 Receptor Agonists
5-HT(4) agonists for GI disorders differ in chemical structure and selectivity for 5-HT(4) receptors. Selectivity for 5-HT(4) over non-5-HT(4) receptors may influence the agent's safety and overall risk-benefit profile. Based on available evidence, highly selective 5-HT(4) agonists may offer improved safety to treat patients with impaired GI motility.