Systematic review: Cardiovascular safety profile of 5-HT 4 agonists developed for gastrointestinal disorders Review uri icon

Overview

MeSH Major

  • Cardiovascular Diseases
  • Gastrointestinal Agents
  • Gastrointestinal Diseases
  • Serotonin 5-HT4 Receptor Agonists

abstract

  • 5-HT(4) agonists for GI disorders differ in chemical structure and selectivity for 5-HT(4) receptors. Selectivity for 5-HT(4) over non-5-HT(4) receptors may influence the agent's safety and overall risk-benefit profile. Based on available evidence, highly selective 5-HT(4) agonists may offer improved safety to treat patients with impaired GI motility.

publication date

  • April 2012

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3491670

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2036.2012.05011.x

PubMed ID

  • 22356640

Additional Document Info

start page

  • 745

end page

  • 67

volume

  • 35

number

  • 7