EGFR exon 19 insertions: A new family of sensitizing EGFR mutations in lung adenocarcinoma Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Lung Neoplasms
  • Mutagenesis, Insertional
  • Receptor, Epidermal Growth Factor

abstract

  • EGFR exon 19 insertions are a newly appreciated family of EGFR-TKI-sensitizing mutations, and patients with tumors harboring these mutations should be treated with EGFR-TKI. While these mutations may be missed through the use of some mutation-specific assays, the addition of PCR product size analysis to multigene assays allows sensitive detection of both exon 19 insertion and deletion mutations.

publication date

  • March 15, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3306520

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-11-2361

PubMed ID

  • 22190593

Additional Document Info

start page

  • 1790

end page

  • 7

volume

  • 18

number

  • 6