Immunologic correlates of the abscopal effect in a patient with melanoma Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal
  • Lung Neoplasms
  • Melanoma
  • Skin Neoplasms

abstract

  • The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). We report a case of the abscopal effect in a patient with melanoma treated with ipilimumab and radiotherapy. Temporal associations were noted: tumor shrinkage with antibody responses to the cancer-testis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibody responses to other antigens after radiotherapy. (Funded by the National Institutes of Health and others.).

publication date

  • March 8, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3345206

Digital Object Identifier (DOI)

  • 10.1056/NEJMoa1112824

PubMed ID

  • 22397654

Additional Document Info

start page

  • 925

end page

  • 31

volume

  • 366

number

  • 10