Carcinoma ex microcystic adenoma of the pancreas: a report of a novel form of malignancy in serous neoplasms. Academic Article uri icon



  • Female 
  • Humans 
  • Middle Aged 

MeSH Major

  • Adenoma 
  • Pancreatic Neoplasms 


  • Serous cystic neoplasms of the pancreas are generally considered benign lesions. Malignant counterparts have been occasionally described, and the diagnosis of malignancy is based solely on the presence of synchronous or metachronous metastases to the lymph nodes or liver, direct tumor invasion into adjacent organs, or vascular invasion. However, these malignant serous cystic tumors are lined by benign-appearing glycogen-rich cuboidal cells, which have been morphologically indistinguishable from benign microcystic serous cystadenoma in all the cases reported so far. We report a unique case of microcystic serous cystadenoma giving rise to carcinoma with distinctive histologic features including signet ring-like cells and solid nests. We believe that this case represents the first case of a cytologically malignant neoplasm arising from a benign serous cystadenoma (carcinoma ex microcystic serous cystadenoma).

publication date

  • February 2012

has subject area

  • Adenoma
  • Female
  • Humans
  • Middle Aged
  • Pancreatic Neoplasms



  • Case Reports
  • Journal Article



  • eng

Digital Object Identifier (DOI)

  • 10.1097/PAS.0b013e3182393dc3

PubMed ID

  • 22189969

Additional Document Info

start page

  • 305

end page

  • 310


  • 36


  • 2