Anti-cocaine vaccine based on coupling a cocaine analog to a disrupted adenovirus. Review uri icon

Overview

MeSH

  • Animals
  • Humans
  • Immunization, Passive

MeSH Major

  • Adenoviridae
  • Cocaine
  • Cocaine-Related Disorders
  • Vaccines

abstract

  • The challenge in developing an anti-cocaine vaccine is that cocaine is a small molecule, invisible to the immune system. Leveraging the knowledge that adenovirus (Ad) capsid proteins are highly immunogenic in humans, we hypothesized that linking a cocaine hapten to Ad capsid proteins would elicit high-affinity, high-titer antibodies against cocaine, sufficient to sequester systemically administered cocaine and prevent access to the brain, thus suppressing cocaine-induced behaviors. Based on these concepts, we developed dAd5GNE, a disrupted E1-E3- serotype 5 Ad with GNE, a stable cocaine analog, covalently linked to the Ad capsid proteins. In pre-clinical studies, dAd5GNE evoked persistent, high titer, high affinity IgG anti-cocaine antibodies, and was highly effective in blocking cocaine-induced hyperactivity and cocaine self-administration behavior in rats. Future studies will be designed to expand the efficacy studies, carry out relevant toxicology studies, and test dAd5GNE in human cocaine addicts.

publication date

  • December 2011

has subject area

  • Adenoviridae
  • Animals
  • Cocaine
  • Cocaine-Related Disorders
  • Humans
  • Immunization, Passive
  • Vaccines

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3369545

PubMed ID

  • 22229312

Additional Document Info

start page

  • 899

end page

  • 904

volume

  • 10

number

  • 8