Copy number losses define subgroups of dedifferentiated liposarcoma with poor prognosis and genomic instability Academic Article uri icon

Overview

MeSH Major

  • DNA Copy Number Variations
  • Genomic Instability
  • Liposarcoma

abstract

  • Dedifferentiation of WDLS is associated with recurrent CNAs in 79% of tumors. In DDLS, loss of 11q23-24 is associated with genomic complexity and distinct morphology whereas loss of 19q13 predicts poor prognosis. CNAs in liposarcoma improve risk stratification for patients and will help identify potential tumor suppressors driving liposarcoma progression.

publication date

  • March 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3294014

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-11-2820

PubMed ID

  • 22241790

Additional Document Info

start page

  • 1334

end page

  • 40

volume

  • 18

number

  • 5