Persistent pulmonary hypertension of the newborn and selective serotonin reuptake inhibitors: Lessons from clinical and translational studies Review uri icon


MeSH Major

  • Depressive Disorder
  • Persistent Fetal Circulation Syndrome
  • Pregnant Women
  • Prenatal Exposure Delayed Effects
  • Serotonin Uptake Inhibitors


  • Two recent studies linking in utero exposure to selective serotonin reuptake inhibitors (SSRIs) with persistent pulmonary hypertension of the newborn (PPHN), a potentially serious but rare respiratory illness, have made clinicians and patients more reluctant to use SSRIs during pregnancy. However, additional clinical studies have associated maternal depression rather than SSRI exposure as a risk factor for PPHN. This review summarizes the current knowledge regarding PPHN pathophysiology, including the role of serotonin and genetic risk factors; the effects of SSRIs on pulmonary vasculature; the possible link between SSRIs and PPHN; and the diagnosis, clinical management, and prognosis of PPHN.

publication date

  • February 2012



  • Review



  • eng

Digital Object Identifier (DOI)

  • 10.1176/appi.ajp.2011.11040553

PubMed ID

  • 22420034

Additional Document Info

start page

  • 134

end page

  • 40


  • 169


  • 2