Beyond pattern recognition: Five immune checkpoints for scaling the microbial threat Review uri icon

Overview

MeSH Major

  • Host-Pathogen Interactions
  • Immunity, Innate
  • Infection
  • Receptors, Pattern Recognition

abstract

  • Pattern recognition by the innate immune system enables the detection of microorganisms, but how the level of microbial threat is evaluated - a process that is crucial for eliciting measured antimicrobial responses with minimal inflammatory tissue damage - is less well understood. New evidence has shown that features of microbial viability can be detected by the immune system and thereby induce robust responses that are not warranted for dead microorganisms. Here, we propose five immune checkpoints that, as defined here, collectively determine the gravity of microbial encounters.

publication date

  • March 2012

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/nri3167

PubMed ID

  • 22362354

Additional Document Info

start page

  • 215

end page

  • 25

volume

  • 12

number

  • 3