Modeling hepatitis C virus infection using human induced pluripotent stem cells Academic Article uri icon

Overview

MeSH Major

  • Hepatitis C
  • Models, Theoretical
  • Pluripotent Stem Cells

abstract

  • Human pathogens impact patient health through a complex interplay with the host, but models to study the role of host genetics in this process are limited. Human induced pluripotent stem cells (iPSCs) offer the ability to produce host-specific differentiated cells and thus have the potential to transform the study of infectious disease; however, no iPSC models of infectious disease have been described. Here we report that hepatocyte-like cells derived from iPSCs support the entire life cycle of hepatitis C virus, including inflammatory responses to infection, enabling studies of how host genetics impact viral pathogenesis.

publication date

  • February 14, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3289320

Digital Object Identifier (DOI)

  • 10.1073/pnas.1121400109

PubMed ID

  • 22308485

Additional Document Info

start page

  • 2544

end page

  • 8

volume

  • 109

number

  • 7