Network deficiency exacerbates impairment in a mouse model of retinal degeneration Academic Article uri icon

Overview

MeSH Major

  • Nervous System Diseases
  • Neural Pathways
  • Optogenetics

abstract

  • Neural oscillations play an important role in normal brain activity, but also manifest during Parkinson's disease, epilepsy, and other pathological conditions. The contribution of these aberrant oscillations to the function of the surviving brain remains unclear. In recording from retina in a mouse model of retinal degeneration (RD), we found that the incidence of oscillatory activity varied across different cell classes, evidence that some retinal networks are more affected by functional changes than others. This aberrant activity was driven by an independent inhibitory amacrine cell oscillator. By stimulating the surviving circuitry at different stages of the neurodegenerative process, we found that this dystrophic oscillator further compromises the function of the retina. These data reveal that retinal remodeling can exacerbate the visual deficit, and that aberrant synaptic activity could be targeted for RD treatment.

publication date

  • February 9, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3285818

Digital Object Identifier (DOI)

  • 10.3389/fnsys.2012.00008

PubMed ID

  • 22383900

Additional Document Info

start page

  • 8

number

  • FEBRUARY 2012