Clarifying the spectrum of driver oncogene mutations in biomarker-verified squamous carcinoma of lung: Lack of EGFR/KRAS and presence of PIK3CA/AKT1 mutations Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Squamous Cell
  • Lung Neoplasms
  • Mutation
  • Oncogenes
  • Proto-Oncogene Proteins
  • Receptor, Epidermal Growth Factor
  • ras Proteins

abstract

  • Our findings suggest that EGFR/KRAS mutations do not occur in pure pulmonary SQCC, and occasional detection of these mutations in samples diagnosed as "SQCC" is due to challenges with the diagnosis of AD-SQC and adenocarcinoma, which can be largely resolved by comprehensive pathologic assessment incorporating immunohistochemical biomarkers.

publication date

  • February 15, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3487403

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-11-2109

PubMed ID

  • 22228640

Additional Document Info

start page

  • 1167

end page

  • 76

volume

  • 18

number

  • 4