Meta-analysis of genome-wide linkage scans for renal function traits
Genetic Predisposition to Disease
Genome-Wide Association Study
Kidney Failure, Chronic
While heterogeneity across populations, methodologies and study designs likely explain this lack of agreement, it is possible that linkage scan methodologies lack the resolution for investigating complex traits. Combining family-based linkage studies with genome-wide association studies may be a powerful approach to detect private mutations contributing to complex renal phenotypes.