Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: Potential role for myeloid and plasmacytoid dendritic cells Academic Article uri icon

Overview

MeSH Major

  • Bifidobacterium
  • Dendritic Cells
  • Forkhead Transcription Factors
  • Probiotics
  • T-Lymphocytes, Regulatory

abstract

  • B. infantis administration to humans selectively promotes immunoregulatory responses, suggesting that this microbe may have therapeutic utility in patients with inflammatory disease. Cross-talk between multiple pattern-recognition receptors and metabolic pathways determines the innate and subsequent T regulatory cell response to B. infantis. These findings link nutrition, microbiota and the induction of tolerance within the gastrointestinal mucosa.

publication date

  • March 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1136/gutjnl-2011-300936

PubMed ID

  • 22052061

Additional Document Info

start page

  • 354

end page

  • 66

volume

  • 61

number

  • 3