Neuroimaging of frontal-limbic dysfunction in schizophrenia and epilepsy-related psychosis: Toward a convergent neurobiology Review uri icon


MeSH Major

  • Epilepsy
  • Frontal Lobe
  • Limbic System
  • Neuroimaging
  • Psychotic Disorders


  • Psychosis is a devastating, prevalent condition considered to involve dysfunction of frontal and medial temporal limbic brain regions as key nodes in distributed brain networks involved in emotional regulation. The psychoses of epilepsy represent an important, though understudied, model relevant to understanding the pathophysiology of psychosis in general. In this review, we (1) discuss the classification of epilepsy-related psychoses and relevant neuroimaging and other studies; (2) review structural and functional neuroimaging studies of schizophrenia focusing on evidence of frontal-limbic dysfunction; (3) report our laboratory's PET, fMRI, and electrophysiological findings; (4) describe a theoretical framework in which frontal hypoactivity and intermittent medial temporal hyperactivity play a critical role in the etiopathology of psychosis both associated and unassociated with epilepsy; and (5) suggest avenues for future research.

publication date

  • February 2012



  • Review



  • eng

PubMed Central ID

  • PMC3339259

Digital Object Identifier (DOI)

  • 10.1016/j.yebeh.2011.11.004

PubMed ID

  • 22209327

Additional Document Info

start page

  • 113

end page

  • 22


  • 23


  • 2